Assembly of Individual Strands Service

In recent years, DNA, as the genetic material of organisms, has been widely used as the basic material for the construction of nanodevices. Its most significant advantage is that it can manipulate molecules at the nanometer scale to achieve precise positioning and programming of target molecules; at the same time, as a biological endogenous substance, DNA has good biocompatibility. The main purpose of DNA nanotechnology is to construct nanodevices using DNA molecules, and then use these nanodevices to regulate the functions of biological systems. DNA nanocage is a nano-scale polyhedron with a certain spatial structure, which is self-assembled by multiple DNA oligonucleotide chains through the principle of base complementary pairing. Studies have shown that DNA nanocage, as a promising nanocarrier, has the advantages of stable structure, good biocompatibility, easy penetration of cell membranes, easy drug loading and surface modification. Now, Creative BioMart Nanocage offer you with professional assembly of individual strands service according to your scientific needs.

Figure 1. One-pot assembly of component strands into DNA cages.

Assembly of Individual Strands Service We Offer

• Creative BioMart Nanocage can construct a DNA cage in a one-pot reaction by directly assembling the components of the DNA strand. We can construct DNA tetrahedrons, which are designed to self-assemble in one step by annealing a single oligonucleotide. Each edge of this tetrahedron contains two double helix loops of DNA, and can be reconfigured to reversibly change its shape in response to specific molecular signals.
• The collaborative assembly solution developed by Creative BioMart Nanocage for DNA tetrahedrons can also be extended to larger polyhedrons.
• Creative BioMart Nanocage can also create a complex, asymmetrical triangular bipyramid DNA nanocage through one-step assembly.
• Creative BioMart Nanocage can construct DNA dodecahedron using trisoligonucleotides. A regular dodecahedron consists of twelve regular pentagonal faces, with three meeting at each vertex to give 30 edges and 20 vertices.

Our Advantages

• Creative BioMart Nanocage has advanced equipment and experienced scientific research team. Our advanced DNA nanocage platform can provide highly reliable and reproducible results.
• Creative BioMart Nanocage can generally complete the scoring service within a week. We will send the labeled and purified samples to customers, and we can provide them according to customer requirements.
• We have established a professional after-sales service team to provide customers with efficient, fast and practical solutions.

Service Procedure

Please inform us of your assembly of individual strands service details through online consultation. We will reply to you in time and provide you with a comprehensive evaluation report on your project, including the feasibility of the project and the detailed experimental plan designed by our professionals. As our condition optimization is completed, the result report and final product will be delivered to you immediately.

Why choose us?

Creative BioMart Nanocage provides professional assembly of individual strands service to meet the scientific research needs of customers. Creative BioMart Nanocage relies on world-class technical expertise, we provide customers with the best quality one-stop assembly of individual strands service, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

Reference

• Arun Richard Chandrasekaran, Oksana Levchenko. Chem. Mater. 2016, 28, 16, 5569–5581.