Ferritin Drug Delivery
From a very general perspective, drug delivery systems (DDS) are nanocarriers composed of lipids and/or polymers and their associated therapeutic agents. Protein cages (hollow protein nanoparticles) have taken center stage in DDS. The delivery of therapeutic proteins is one of the greatest challenges in treating human diseases. In this framework, ferritin occupies a very special place. Due to their hollow spherical structure, they are used as modular nanocages for the delivery of anticancer drugs. Ferritins share many other advantages like DDS: they can be produced in high yields as recombinant proteins and are easy to purify, they are biodegradable, and because of their size, they can accumulate in highly vascularized tumor tissues ( Enhanced Penetration and Retention (EPR) effect). Now, Creative BioMart Nanocage provides you with a variety of ferritin drug delivery technology services to meet your scientific research needs.
Figure 1. Illustration of drug loading strategies and modular ferritin platforms. (Khoshnejad M, 2019)Ferritin Drug Delivery Technology
- Most protein drugs require efficient intracellular delivery to exert their therapeutic effects. A major disadvantage of their use is indeed the difficulty of delivering them into target cells due to their physicochemical properties, such as three-dimensional structure, hydrophilic/hydrophobic properties, and sensitivity to chemical modification. Therefore, Creative BioMart Nanocage can increase the water solubility of ferritin through chemical modification, biological modification, etc.
- Through chemical modification and molecular reengineering of ferritin, we have generated a multifunctional nanocarrier platform capable of delivering a wide range of therapeutic and imaging agents.
- We provide multivalent anchoring of biological targets through targeting moieties conjugated to the outer surface of ferritin.
- We will provide key characteristics of ferritin-loaded drugs including: routes of administration and delivery, therapeutic targets, DDS and drug cargo and their characteristics - pharmacokinetics, size, biocompatibility, durability, etc. In addition to these research parameters, important translational parameters to consider when designing an effective targeted drug delivery system include scale-up, quality control, and compliance with production costs.
Ferritin Drug Delivery Approaches We Offer
- Ferritin-based nanotherapeutics are developed by loading the following drugs in ferritin nanocages, including but not limited to
- Besides, we can also load metal nanoparticles on ferritin. The drug-loading strategies used include pH- or salt-induced ferritin breakdown/recombination, diffusion-based encapsulation, and direct binding of the drug to the ferritin surface.
- Khoshnejad M, Parhiz H, Shuvaev V V, et al. Ferritin-based drug delivery systems: Hybrid nanocarriers for vascular immunotargeting. Journal of Controlled Release, 2018, 282:229.
Provided by Clients
Please inform us of your specific ferritin drug delivery technology service details, and we can provide customized solutions for different projects.
Why Choose Us?
Creative BioMart Nanocage is a specialized nanocage drug delivery technology company that can focus on services such as ferritin drug delivery in an efficient and precise manner. Creative BioMart Nanocage is a leading nanocage drug delivery company, offering a trusted suite of services and solutions, especially our extensive experience in ferritin drug delivery. We ensure your efficient standard workflow and high-quality data. With outstanding staff, state-of-the-art technology and state-of-the-art facilities, Creative BioMart Nanocage is able to provide you with a comprehensive range of biofilm detection technologies.
