Biopolymer Drug Carriers Design
Introduction to Biopolymer Drug Carriers
Biopolymers are polymers that are produced from living organisms, which are classified in three groups: polysaccharides, proteins and nucleic acids. Biopolymers are suitable materials as nanoparticles for clinical application due to their versatile traits, including biocompatibility, biodegradability and low immunogenicity. It is important to control particle size, charge, morphology of surface and release rate of loaded molecules to use biopolymer-based nanoparticles as drug/gene delivery carriers.
Protein/Polypeptide nanoparticles and polysaccharides are two main class of biopolymers.
- Proteins are naturally-derived polymers that are advantageous in their biodegradability, low toxicity, nonantigenicity, high nutritional value, high stability and binding capacity of various drugs. They have abilities of emulsification, gelation, forming and water binding capacity. Because of these unique properties that are different from any synthetic polymers, protein-based nanocarriers are promising candidates for drug and gene delivery.
- Polysaccharides are naturally derived polymers with storage and structural functions, which are one of the main constituents in biological systems such as the glycocalyx and the extracellular matrices. They are highly stable, biocompatible and biodegradable. Introduction of hydrophobic segments into hydrophilic polysaccharide backbones enables to form self-assembled structures such as micelles, particles and hydrogels.
Biopolymer Drug Carriers Design Services We Offer
Creative BioMart Nanocage can provide you with a series of biopolymer drug carriers design services, from production to characterization, you only need to briefly describe your experimental needs for us, and we will provide you with professional services to meet your scientific research needs. Our service include but not limited to:
Liposome
Liposomes possess particular properties such as excellent biocompatibility and biodegradability, highly efficient drug encapsulation, sustained release, long shelf-life and low toxicity. At Creative BioMart Nanocage, versatile properties of liposomes are manipulated by modifying liposome formulations to address different drug delivery considerations in treatment of cancer, antibacterial, antifungal, immunomodulation, diagnostics, etc.
Heparosan
Heparosan is superior in drug delivery due to its perfect biocompatibility and stability. We provide heparosan production, characterization and modification services to support our customers' novel therapy development programs.
Cyclodextrins
Cyclodextrins (CDs) are cyclic oligosaccharides formed from multiple glucose units linked by alpha-1, 4-glucoside bonds. Cyclodextrins are widely used in pharmaceutical preparations, including oral, injection, eye administration and other ways. Creative BioMart Nanocage continues contributing to the development of novel drug delivery systems to provide various type of cyclodextrin-based carriers for different types of drugs.
Lipid Nanoparticles
Lipid nanoparticle (LNP) is an advanced non-viral gene delivery system and the first nano-drug delivery platform to successfully proceed from concept to clinical application. Creative BioMart Nanocage prodeced a large number of different types of new lipids, and conducted a comprehensive evaluation of the payload, potency, and safety of these LNPs for nucleic acid delivery.
Fig1. Schematic representation of biopolymers used to overcome the traditional barrier methods from conventional drug delivery methods. (Tanima Bhattacharya, 2023)
Why choose us?
- The expert team of Creative BioMart Nanocage has a multidisciplinary background, including medicine, pharmacy, molecular biology, bioinformatics, etc. We attach great importance to innovation and practice.
- We have advanced equipment and production technology. Production is completed according to your requirements in a limited time, while quality control and evaluation is carried out.
- We can provide customized services. Not limited to the types of services mentioned above, products can be designed according to your specific needs.
- Safe and reliable production process.
Creative BioMart Nanocage provides professional biopolymer drug carriers design services to meet the scientific research needs of customers. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.
References
- Jamroży, M.; et al. Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms. Int J Mol Sci. 2024;25(2):786.
- Bhattacharya, T.; et al. Advancement in Biopolymer Assisted Cancer Theranostics. ACS Appl Bio Mater. 2023;6(10):3959-3983.
