DNA Nanocage Fluorescent Dye Modification

Besides being the carrier of genetic information, DNA is also an excellent biological organizer to establish well-designed nanostructures in the fields of material engineering, nanotechnology, and biomedicine. DNAbased materials represent a diverse nanoscale system primarily due to their predictable base pairing and highly regulated conformations, which greatly facilitate the construction of DNA nanostructures with distinct shapes and sizes. Integrating the emerging advancements in bioconjugation techniques, DNA nanostructures can be readily functionalized with high precision for many purposes ranging from biosensors to imaging to drug delivery. Recent progress in the field of DNA nanotechnology has exhibited collective efforts to employ DNA nanostructures as smart imaging agents or delivery platforms within living organisms.

Figure 1. Molecular imaging and drug delivery with DNA nanocages. (Jiang D, England CG, Cai W.2016)

Research progress in nucleic acid modification of DNA nanocage

Kim et al. [3] used a DNA tetrahedral cage (Td) labeled with the fluorescent dye Cy5 as an imaging probe for sentinel lymph nodes (SLN). The results show that Cy5-Td has good biocompatibility and is a promising nanomaterial for in vivo imaging.

Figure 2. Optical tomographic images of a Cy5-Td-injected mouse were obtained by the IVIS imaging system. SLNs in the left axillary are specifically visualized by the fluorescence emission of Cy5. (Kim KR, Lee YD, Lee T, et al.2013)

DNA Nanocage Nucleic Acid Conjugate We Offer

DNA nanocages can enter living cells non-invasively and efficiently, and can maintain a complete structure for a certain period of time. Therefore, the modification of DNA nanocages with fluorescent dyes can be used for live cell imaging. DNA nanocage has high biocompatibility and flexibility of fluorescence modification, and is a promising material for in vivo imaging. We offer you with the following services but not limited to:

• Creative BioMart Nanocage' DNA nanocage fluorescent dye modification service has a variety of labels and conjugate options to provide customers with personalized solutions to meet their specific needs.
• We will help you choose the appropriate modification according to your specific needs and optimize the modification method.
• Creative BioMart Nanocage can generate different light under ultraviolet excitation by adjusting the ratio of donor fluorescent molecules and acceptor fluorescent molecules.

Our Advantages

• Creative BioMart Nanocage specializes in DNA nanocage modification service and we are committed to contributing to more customers.
• Creative BioMart Nanocage will complete your project on time and efficiently. We have professional after-sales service: which has been established to provide customers with efficient, fast, practical and feasible solutions.
• We have established a professional after-sales service team to provide customers with efficient, fast and practical solutions.

Service Procedure

Please inform us of your DNA nanocage fluorescent dye modification service details through online consultation. We will reply to you in time and provide you with a comprehensive evaluation report on your project, including the feasibility of the project and the detailed experimental plan designed by our professionals. As our condition optimization is completed, the result report and final product will be delivered to you immediately.  

Why choose us?

Creative BioMart Nanocage provides professional DNA nanocage fluorescent dye modification service to meet the scientific research needs of customers. Creative BioMart Nanocage relies on world-class technical expertise, we provide customers with the best quality one-stop DNA nanocage fluorescent dye modification service, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

References

• Arun Richard Chandrasekaran, Oksana Levchenko. Chem. Mater. 2016, 28, 16, 5569–5581.
• Jiang D, England CG, Cai W. DNA nanomaterials for preclinical imaging and drug delivery. J Control Release, 2016, 239: 27-38.'
• Kim KR, Lee YD, Lee T, et al. Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron. Biomaterials, 2013, 34( 21):5226-5235.