Virus-like Nanoparticles (VLPs)
Introduction to Virus-like Nanoparticles (VLPs)
Nanoparticles (NPs) based drug delivery agents, including liposomes, polymer NPs, metal NPs and protein-based NPs have the potential to provide a safe targeted delivery by encapsulating therapeutic cargo inside the particle. An alternate type of drug delivery NP that is showing promise is the VLP. VLPs are self‐assembled, homogeneous NPs derived from the coat proteins of viral capsids. They typically lack their natural genome and are therefore noninfectious. VLPs are an emerging class of targeted delivery vehicles with the potential to overcome the limitations of other NPs. In recent years, several groups have shown that VLPs can pack and deliver therapeutic cargo such as chemotherapeutic drugs, siRNA, RNA aptamers, proteins, and peptides.
VLPs are self-assembled protein-based NPs derived from the coat proteins of viral caspids. They are highly uniform and easily to be expressed in bacteria. Additionally, they lack their natural genome and therefore are non-infectious. VLPs can be classified based on the virus type, including animal virus-based, bacteriophage-based and plant virus based, etc. To improve the specificity of VLPs to intended cells and their stability while they are in the bloodstream and the interstitial space, Creative BioMart Nanocage conducted significant amount of work on the surface functionalization of the VLPs.
Fig1. Structures of the six of the most actively developed VLPs from: one animal virus, three bacteriophages, and two plant viruses. (Marcus J Rohovie, 2017)
Service Details
We will provide you with professional genetic modification, expression, purification and characterization services. We can also provide a variety of detection methods including western blot, enzyme-linked immunosorbent assay (ELISA) or other methods according to your scientific research needs. During the procedure, some aspects are very important like surface functionalization, cargo loading and retention and VLPs formation. We will fully understand the type of drug that needs to be delivered, the target cell or tissue, the purpose, etc. to ensure you of high quality delivery.
Work Flow of VLPs Service
Why choose us?
- Our R&D team has a wealth of theoretical knowledge and practical experience, and can design and synthesize VLPs with specific functions according to customer needs.
- Our engineered VLPs are widely used. They are with design flexibility and complexity have been designed for biomedical applications.
- We can offer customized services to meet your needs.
- Ensure safety and reliability.
To improve the specificity of VLPs to intended cells and their stability while they are in the bloodstream and the interstitial space, Creative BioMart Nanocage conducted significant amount of work on the surface functionalization of the VLPs. If you are interested in our services, please do not hesitate to contact us for more details.
References
- Rohovie MJ; et al. Virus-like particles: Next-generation nanoparticles for targeted therapeutic delivery. Bioeng Transl Med. 2017;2(1):43-57.
- Taghizadeh, MS; et al. Virus-like particles (VLPs): A promising platform for combating against Newcastle disease virus. Vaccine: X. 2024, 16 100440.
