DNA Nanocage Loading siRNA Service
Research Progress in DNA Nanocage Loading siRNA
Wang et al. constructed a triangular DNA nanocage (ssRNA-TNP) loaded with single-stranded mTOR-siRNA to inhibit mTOR. This system can improve the stability of siRNA, efficiently transfect NCI-H292 cells, and can effectively inhibit the expression of mTOR. It is expected to become a non-viral gene delivery system.
Figure 1. An mTOR single stranded siRNA is hybridized with DNA triangular self-assembled nanoparticles (ssRNA-TNP) as an efficient system for gene delivery via macropinocytosis and clathrin-mediated endocytosis pathways.( Wang Y, You Z, Du J, et al.2016)DNA Nanocage Loading siRNA Service We Offer
- The development of advanced nucleic acid drug delivery systems is of great significance for achieving optimal gene delivery. Self-assembled nucleic acid nanocages are an excellent platform for the delivery of nucleic acids and other small molecule drugs. Creative BioMart Nanocage provide DNA nanocage loading siRNA service with better stability and higher transfection efficiency; therefore, it may become a new non-viral nanosystem for gene delivery.
- Creative BioMart Nanocage can assemble DNA nanocages capable of encapsulating siRNA. Our DNA nanocage has low toxicity, high yield and minimal DNA consumption; it can independently contain siRNA drugs; at the same time, it can protect siRNA drugs from being degraded by nucleases, and can realize intelligent release of drugs.
Our Advantages
- Creative BioMart Nanocage DNA nanocage loading siRNA service can improve stability, reduce immune irritation, realize the intelligent release of drugs and the treatment of various tumors. The application has certain universality and adaptability.
- Creative BioMart Nanocage will complete your project on time and efficiently. We have professional after-sales service: which has been established to provide customers with efficient, fast, practical and feasible solutions.
- Our researchers usually require a full understanding of DNA nanocage experiments. They can quickly understand the project situation through a simple description, and quickly establish a feasible research plan according to the client's needs, saving a lot of time for literature research.
Figure 2. siRNA encapsulation and release. (Bujold KE, Hsu JC, Sleiman HF.2016)Why Choose Us?
Creative BioMart Nanocage has a DNA nanocage drug delivery platform that can help you meet your drug discovery needs. Our services can be contracted according to confidentiality clauses and other specific conditions negotiated with customers. Please contact us for more details. Creative BioMart Nanocage has close ties in academia and industry, so it has accumulated a wealth of experience and can provide our customers with the latest solutions.
References
- Wang Y, You Z, Du J, et al. Self-assembled triangular DNA nanoparticles are an efficient system for gene delivery. J Control Release, 2016, 233: 126-135.
- Bujold KE, Hsu JC, Sleiman HF. Optimized DNA "nanosuitcases" for encapsulation and conditional release of siRNA. J Am Chem Soc, 2016, 138(42): 14030-14038.
