Engineered Exosomes for Nucleic Acid Delivery
Exosomes are nanoscale extracellular vesicles with a lipid bilayer membrane structure that can be secreted by most cells in the body. Animal exosomes are about 30 ~ 150 nm, and plant exosomes are about 50 ~ 1000 nm. Most types of cells can secrete exosomes. Exosomes are present in various body fluids, including blood, tears, urine, saliva, breast milk. Those vesicles are loaded with nucleic acids, proteins, lipids, and other active biomolecules. After being released into the extracellular environment, those vesicles are delivered to recipient cells. Thus, extracellular vesicles as biological nano-carriers, have an enormous potential in drug delivery system.
Exosomes are an important means of cellular information transfer in the body. It has high circulatory stability, biocompatibility, physical and chemical stability, high delivery efficiency, low immunogenicity, low toxicity, and targeting. Therefore, the use of exosomes as carriers can achieve high efficiency and selectivity of nucleic acid delivery and have a wide range of application prospects.
Engineered exosomes are exosomes that have undergone surface modification and internal molecular modification. After appropriate modifications, engineered exosomes can efficiently and precisely deliver nucleic acids or drugs to disease sites, improve the regulation of target tissues and organs, and at the same time reduce the side effects associated with treatment, thus becoming a hot research topic.
Creative BioMart Nanocage offers comprehensive customization services for engineered exosomes for nucleic acid delivery based on your scientific needs.
Customized Services for Engineered Exosomes for Nucleic Acid Delivery
We offer customized services for engineered exosomes for nucleic acid delivery. Through our technology and expertise, customers can obtain the following services:
1. Customized Solutions
We provide customized solutions for vesicular nucleic acid delivery according to the specific needs of our customers, as well as technical support and cooperation.
2. Isolation/Synthesis and Preparation of Exosomes
Using advanced biotechnological tools and purification methods, we can isolate/synthesize, and prepare functionally customized exosomes to meet customer-specific needs.
3. Loading Nucleic Acids into Exosomes
We can successfully load customer-supplied nucleic acids (e.g., DNA, RNA, etc.) into exosomes by electroporation, liposome-exosome hybridization, transfection with specific reagents, etc., and ensure high encapsulation efficiency and stability.
4. Surface Modification and Functional Enhancement
To further enhance the nucleic acid delivery effect and targeting, we can perform surface modifications (including biological modifications, immunological modifications, physical modifications, and chemical modifications) on the vesicles, such as adding targeting peptides, antibodies, magnetic particles, and sodium bicarbonate.
5. Product Delivery
Our engineered exosomes have excellent cargo delivery and release, and can efficiently release nucleic acids into target cells.
Service Procedure
Please let us know the details of your customized exosome for nucleic acid delivery through online consultation. We will respond to you promptly and provide you with a comprehensive project evaluation report, including the feasibility of the project and detailed experimental protocols designed by our professional staff.
Our Advantages
Customize our engineered exosomes for nucleic acid delivery services and you will benefit from the following advantages:
High-quality technology: We use advanced technology platforms and high-quality reagents to ensure the delivery of high-quality and stable engineered exosomes.
Customized service: We provide flexible and customized services to design and optimize experimental protocols according to customer needs.
Contact Us
Ready for applications in your research on engineered exosomes for drug delivery? Contact our team at Creative BioMart Nanocage today to discuss your project requirements and explore how our services can accelerate your discoveries. We look forward to collaborating with you and providing innovative solutions to advance your scientific endeavors.
