Interior Modification of Protein Nanocages

The interior cavity of the protein nanocages provides an ideal containment for molecular cargos. Tailoring the cage interior increases the encapsulation efficiency, binding affinity and modulated release profile. Genetic or chemical alterations can be made at precise locations to manipulate the nucleation and attachment of molecules. Molecular cargos such as small molecules, peptides, protein drugs, RNA/DNA drugs, imaging agents and polymers have been encapsulated and released from the interior of protein nanocages. Now, Creative BioMart Nanocage can offer you with professional professional interior modification service of protein nanocages, if you have any needs in this regard, please feel free to contact us.

Interior Modification of Protein Nanocages We Offer

Creative BioMart Nanocage focuses on comprehensive services for interior modification service of protein nanocages. Creative BioMart Nanocage has well-trained technicians and the most advanced nanocage modification technology to meet your scientific research needs. Our scope of services includes but is not limited to:

• Antibodies are potential cargoes for larger protein nanocages (such as domes). Creative BioMart Nanocage can modify the interior of the nanocage by introducing cysteine residues. This modification promotes the covalent attachment of dye molecules, drugs and other active molecules through disulfide bonds.
• Creative BioMart Nanocage can be attached to the nanocage structure by the introduction of phenylalanine.
• Creative BioMart Nanocage can be attached within the nanocage structure through the introduction of lipid substances and polymers. The attachment of polymer chains to the interior surface offers spatial control of reactive sites, which has been shown to stabilize cages.
• Creative BioMart Nanocage can introduce cysteine reactive residues through genetic manipulation, creating a polymer network in the proteincage.

Figure 1. Design of protein nanocage-polymer hybrids. (Abedin, M.J. et al.2009)

Our Advantages

• Creative BioMart Nanocage can efficiently generate highly functionalized protein nanocages, which can be easily loaded with targeting moieties, therapeutic agents and/or imaging agents.
• Creative BioMart Nanocage will complete your project on time and efficiently. We have professional after-sales service: which has been established to provide customers with efficient, fast, practical and feasible solutions.
• We have established a professional after-sales service team to provide customers with efficient, fast and practical solutions.

Service Procedure

Please inform us of your interior modification of protein nnocages project details through online consultation. We will reply to you in time and provide you with a comprehensive evaluation report on your project.

Why choose us?

Creative BioMart Nanocage provides professional interior modification of protein nanocages service to meet the scientific research needs of customers. Creative BioMart Nanocage relies on world-class technical expertise, we provide customers with the best quality one-stop Interior Modification of Protein Nanocages, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

Reference

• Bhaskar S , Lim S . Engineering protein nanocages as carriers for biomedical applications. Npg Asia Materials, 2017, 9(4):e371.