Origami-based Assembly Service

DNA nanocage as a drug carrier has many advantages: (1) The structure is clear and predictable, the inside of the cage has a porous structure, a large space, and a high load; (2) It can respond to changes in the external environment and release drugs intelligently; (3) The cytotoxicity is small, and it will not cause serious immune stimulus reaction, and is relatively safe; (4) It can protect the contained drug from the external environment; (5) It has good stability and is not easy to be degraded by ribozymes; ( 6) DNA nanocage does not require transfection reagents, can directly enter living cells, and has good biocompatibility; (7) DNA nanocage has a wealth of structural modification sites, and the targeting function can be achieved through modification. Therefore, DNA nanocages have good application prospects in drug carriers, biological detection, cell imaging, and materials science.

Figure 1. DNA origami strategy.

Origami-based Assembly Service We Offer

• The difference between DNA origami and DNA patch self-assembly is that DNA origami uses the backbone and scaffold instead of the patch.
• Creative BioMart Nanocage uses short single-stranded DNA as a scaffold to guide and fix long single-stranded DNA (usually the M13 phage genome or its derivatives) for repeated folding.
• Creative BioMart Nanocage utilizes the programmability of DNA to complement the long and short chains at specific positions to obtain the desired shape.
• The origami-based assembly service provided by Creative BioMart Nanocage no longer needs to consider the symmetry of the sequence between each chain, and can synthesize complex network DNA nanocages simply and quickly. DNA origami technology is mainly used to construct two-dimensional shapes and can also be used to construct three-dimensional structures. It has been used to synthesize a series of DNA polyhedrons. This method provides the possibility to synthesize complex and bulky DNA nanocages in the future.

Our Advantages

• Creative BioMart Nanocage has advanced equipment and experienced scientific research team. Our advanced DNA nanocage platform can provide highly reliable and reproducible results.
• Creative BioMart Nanocage can generally complete the scoring service within a week. We will send the labeled and purified samples to customers, and we can provide them according to customer requirements.
• We have established a professional after-sales service team to provide customers with efficient, fast and practical solutions.

Service Procedure

Please inform us of your origami-based assembly service details through online consultation. We will reply to you in time and provide you with a comprehensive evaluation report on your project, including the feasibility of the project and the detailed experimental plan designed by our professionals. As our condition optimization is completed, the result report and final product will be delivered to you immediately.

Why choose us?

Creative BioMart Nanocage provides professional origami-based assembly service to meet the scientific research needs of customers. Creative BioMart Nanocage relies on world-class technical expertise, we provide customers with the best quality one-stop origami-based assembly service, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

Reference

• Arun Richard Chandrasekaran, Oksana Levchenko. Chem. Mater. 2016, 28, 16, 5569–5581.