Polymer-Drug Conjugates
Introduction to Polymer-Drug Conjugates
Polymer-drug Conjugates (PDCs) are a class of highly targeted drug delivery systems that improve pharmacokinetic properties and reduce side effects by attaching therapeutic drugs directly or via splice molecules to polymer scaffolders. The compositions of the PDCs are divided into three different units: i.e., a solubilizing zone, drug–polymer chemical linkers, and a transport system.
Some of the polymers are conjugated with bioactive drug molecules include cellulose derivatives, poly (N-vinyl pyrrolidone) and poly (ethylene glycol) (PEG). The resulting polymer bioconjugates are characterised by improved properties such as reduced immunogenicity, decreased antibody recognition, increased in vivo residence time, increased drug targeting specificity and bioavailability, and improved pharmacokinetics.
Fig1. Basic concept of polymer–drug conjugates based on the Ringsdorf model. (Varaporn Buraphacheep Junyaprasert, 2023)
Service Details
At Creative BioMart Nanocage, besides the widely used PEG, alternative natural and synthetic polymers are also being examined, such as polyoxazolines, poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA), poly(oligoethylene glycol methyl ether methacrylate) (POEGMA), and hydroxyethyl starch. Customized polymerization services are also available for designing specific polymer-drug conjugates.
- Polyoxazoline: This is a polymer with good biocompatibility and biodegradability that can be used as a carrier for drug delivery.
- PHPMA: This is a water-soluble polymer that, due to its good solubility and stability, is often used in the preparation of slow-release preparations of water-soluble drugs.
- POEGMA: This is a polymer with good biocompatibility and biodegradability, and the polyethylene glycol chain segment in its structure can provide good water solubility, making it an ideal drug delivery vehicle.
- Hydroxyethyl starch: This is a natural polysaccharide substance with good biocompatibility and biodegradability, and can be used as a carrier for drug delivery.
How Can We Help?
- Drug selection: Determine the drug molecule to be delivered, taking into account its chemical properties, activity and stability.
- Polymer design: Design the appropriate polymer carrier according to the nature of the drug and the therapeutic objective. This may include selecting suitable monomers, controlling molecular weight, introducing specific functional groups, etc.
- Coupling strategy: Develop an effective coupling strategy to ensure a stable connection between the drug molecule and the polymer carrier. This may involve a variety of chemical reactions such as click chemistry, esterification reactions, and amide bond formation.
- Functionalization: In order for the polymer-drug conjugate to have targeting or other specific functions, it may be necessary to introduce additional functional groups, such as targeting ligands, fluorescent labels, or Ph-sensitive groups.
- Synthesis and characterization: Polymer-drug couplings are synthesized on a laboratory scale and characterized in detail by nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), mass spectrometry (MS) and other techniques.
- Bioactivity assessment: To evaluate the bioactivity and cytotoxicity of polymer-drug couplings to ensure their therapeutic efficacy and safety.
Why choose us?
- The expert team of Creative BioMart Nanocage has a multidisciplinary background.
- We will complete your project on time according to your scientific research needs.
- Quality and thorough knowledge of regulations
- We have a complete production process and verification methods.
Creative BioMart Nanocage provides PDCs design services to meet the scientific research needs of customers. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.
Reference
- Junyaprasert, V.B., Thummarati, P. Innovative Design of Targeted Nanoparticles: Polymer-Drug Conjugates for Enhanced Cancer Therapy. Pharmaceutics. 2023;15(9):2216.
