Protein Nanocage Genetic Modification Service

Genetic engineering of protein nanocages gives rise to uniform orientation of the inserted peptide and protein, resulting in a precise distribution of functional moieties on the surface of the cages. Knowledge of the protein crystal structure allows recombinant incorporation of peptides and/or entire proteins at N- or C-termini or within loop regions of nanocage. Many studies have directly inserted functional peptide/proteins to the surface of the protein nanocages in purpose of enhancing molecule absorption and interaction with cells of target tissue. These studies serve a role as a foundational basis for the development and implementation of drug delivery systems. In another matter in particular, recombinant incorporation of therapeutic peptide/protein may prove to be one of the most effective drug loading mechanisms. Modified nanocages constructed with additional genes (i.e. therapeutic peptide/protein) require no additional processing for use as a drug delivery vehicles. Now, Creative BioMart Nanocage provides professional protein nanocage genetic modification services according to your scientific needs.

Protein Nanocage Genetic Modification Service We Offer

• The RGD amino acid sequence has affinity for integrin receptors up-regulated by tumor vascular endothelial cells, and is the most widely used in various studies. Creative BioMart Nanocage can bind the peptide to the surface of the protein nanocage, which can enhance the transfer of in vivo models to tumor tissues.
• Epidermal growth factor receptor (EGFR) is also overexpressed in many tumor types, making it a suitable target. Creative BioMart Nanocage uses EGF ligands to display on the surface of the nanocage to enhance tumor specificity.
• Creative BioMart Nanocage couples the EGFR targeting affinity conjugate with cationic peptide and cell penetrating peptide to the nanocage to effectively deliver siRNA.

Our Advantages

• Creative BioMart Nanocage cooperates with scientists from many pharmaceutical and biotechnology companies. We have a wealth of knowledge and experience to provide quality assurance services.
• Creative BioMart Nanocage will complete your project on time and efficiently. We have professional after-sales service: which has been established to provide customers with efficient, fast, practical and feasible solutions.
• We have established a professional after-sales service team to provide customers with efficient, fast and practical solutions.

Service Procedure

Please inform us of your protein nanocage genetic modification services details through online consultation. We will reply to you in time and provide you with a comprehensive evaluation report on your project.

Why choose us?

Creative BioMart Nanocage provides professional protein nanocage genetic modification services to meet the scientific research needs of customers. Creative BioMart Nanocage relies on world-class technical expertise, we provide customers with the best quality one-stop protein nanocage genetic modification services, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

Reference

• Lee E J, Na K L, Kim I S . Bioengineered protein-based nanocage for drug delivery. Advanced drug delivery reviews, 2016, 106(Pt A).