Responsive Polymer
Introduction to Responsive Polymer
Use of field responsive or "smart" polymers seems a promising approach as they can achieve delivery at the appropriate time and site of action, entrapped drugs in response to specific physiological triggers.
In current cancer treatment most polymeric nanomedicines cannot deliver drugs/genes/siRNA into the diseased sites and cells on-demand due to the biological barriers (vascular wall, tumor tissue, tumor cells) that the polynanomedicines have to overcome. Thereby, the stimuli-responsive polymeric nanomedicines that are triggered by external and internal stimuli such as pH, temperature, light, ultrasound, electronic and magnetic fields, biomolecules and enzymes, might solve this problem and realize on-demand dosing. For example, light responsive polymeric nanocarrier can achieve photocleavage reaction and cargo release under the controllable phototriggered reaction.
Fig1. Schematic representation of two basic approaches used in the formation of pH-responsive drug delivery. (Udaykumar Vegad, 2023)
Service Details
Over many decades, interest in stimuli-responsive polymers has increased, and Creative BioMart Nanocage has done great deal of work in developing new smart polymers. Below are examples of stimuli responsive materials that we have been working with. In addition, our research and development team is constantly exploring new polymer materials and design methods to maintain technological leadership and provide customers with the best solutions.
| Stimuli | Responsive materials |
|---|---|
| Light responsive (UV NIR) | Alkoxyphenacyl based polycarbonate; Azobenzene (AZO), spiropyran (SP), or 2-diazo-1,2 naphthoquinone (DNQ) modified polymer; O-nitrobenzyl (NB) and coumarin incorporated copolymers. |
| Thermo-responsive | PLGAPEGPLGA: Polybenzofulvene; Orthoester-containing PEG-PtNEA block copolymer; Poly(Nisopropylacrylamide) (PNIPAAm) based hydrogel. |
| pH-responsive | PEG-PPG-PEG; Polylacrylamide)-g-carrageenan and sodium alginate; chitosan-o-nitrobenzyl succinate conjugates. |
| Ultrasound-responsive | PLA-b-PEG; PEO-PPO-PEO; PEOb-PTHPMA; Nano-peptisomes. |
| Electro-responsive | Poly(dimethylsiloxane); Poly(2-acrylamido-2-methylpropane sulphonic acid-co-n butyimethacrylate). |
| Bio-responsive | Glucose-responsive; enzyme-responsive copolymer (protein kinase A, HRP, etc.) |
Why choose us?
- Provide customized design solutions to meet the specific needs of customers.
- Ensure the safety, effectiveness and stability of drug delivery systems.
- Provide comprehensive technical support and after-sales service to reduce usage problems.
- Adhere to strict quality control standards to ensure product quality and consistency.
- A variety of responders are available to respond sensitively to external stimuli such as temperature, pH, and magnetic fields. It can also support a variety of drugs and bioactive molecules.
Creative BioMart Nanocage has team members with a high level of expertise and extensive experience. Therefore, we can provide comprehensive, professional, one-stop solutions to our clients. If you have any questions about responsive polymer production and processing, please feel free to contact us.
References
- Clerc, M.; et al. Visible light-responsive materials: the (photo)chemistry and applications of donor-acceptor Stenhouse adducts in polymer science. Chem Soc Rev. 2023;52(23):8245-8294.
- Vegad, U.; et al. pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. Front Bioeng Biotechnol. 2023;11:1270364.
