Exosomes
Introduction to Exosomes
Exosomes are cell-derived vesicles with a diameter of 30-100 nm. The composition of exosome mainly includes a bi-layer lipid membrane, and various types of proteins and nucleic acids. As a medium of information exchange and material transport between cells, exosomes are considered to be a promising drug delivery carrier due to their nano-size, good biocompatibility, natural targeting, and easy modification. When exosomes are used as drug carriers, the drug is encapsulated within the exosome and subsequently transported through body fluids to the disease site, avoiding an immune response, and thus being rapidly cleared.
Exosomes, as delivery carriers, combine the advantages of cell-based drug delivery and nanomaterials, with their superior biocompatibility and nanosize enabling effective drug delivery. Compared with cell-based drug delivery, exosomes not only inherit most of the functions of source cells but are also easier to control and store and are safer. In addition, compared with nanomaterial-based drug delivery systems, the lipid bilayer, surface membrane proteins, and nanosized structure of exosomes ultimately enable them to overcome various biological barriers, low immunogenicity, natural targeting, and stability for long-distance delivery in vivo
Fig1. The isolation, identification, drug loading, and modification of exosomes as drug carriers for tumor therapy. (Qian Yang, 2024)
Service Details
We will provide you with professional exosomes formation, isolation, characterization, drug loading, and modification services. We can also provide exosomes bioactivity analysis services according to your scientific research needs, such as biocompatibility, drug delivery capacity and efficiency, etc. We provide a full range of services from drug design and exosome engineering to clinical trials, including technical support, data analysis and project management. Based on multiple approaches to quality control and safety assessment, we ensure high standards and compliance of exosomal drug carriers.
Our services of exosomes include workflows for all of these processes.
- Donor cell screening and characterization
- Drug loading
- Targeted modification
- Effective quality control methods
Why choose us?
- Drug delivery solution experts
- Strong scientific background
- Wild-rage services including customized services
- Unique technologies for drug industries
- We have a strict quality management system to provide customers with efficient, fast and reliable solutions.
Creative BioMart Nanocage is your reliable partner in studying of novel drug delivery systems. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.
References
- Yang, Q., et al. Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application. J Nanobiotechnology. 2024, 22,1 41.
- Baruah, H., et al. Exosome: From biology to drug delivery. Drug Deliv Transl Res. 2024, 10.1007/s13346-024-01515-y.
