Cyclodextrins

Introduction to Cyclodextrins

Cyclodextrins (CDs) are a family of cyclic oligosaccharides with hydrophilic outer surface and lipophilic cavity. They possess a unique ability to act as molecular containers by entrapping drugs in their internal cavity. No covalent bonds are formed or broken during drug CD complex formation, therefore serving as a convenient route to increase aqueous solubility of poorly soluble drugs, and also to increase their bioavailability and stability.

In general, the ability of natural cyclodextrins and their hydrophilic derivatives to entrap guest molecules can be modulated by their cavity size and substituent group on the sugar ring. Currently there are more than 50 different pharmaceutical products worldwide containing drug/cyclodextrin complexes on the market.

Fig1. α-, β-, and γ-cyclodextrin molecules and derivatives in drug delivery. (Gergely Kali, 2024)

Advantages of Cyclodextrins

As a drug carrier, cyclodextrins have the following advantages:

• Increased solubility: Hydrophobic cavities of cyclodextrins can contain hydrophobic drug molecules, thus significantly improving their solubility and stability in aqueous solutions.
• Improved bioavailability: By increasing the solubility and stability of the drug, cyclodextrins can improve the bioavailability of the drug.
• Reduce side effects: cyclodextrins can reduce the toxicity and irritation of the drug and reduce adverse reactions.
• Controlled release: Cyclodextrins can achieve slow and targeted release of the drug by adjusting the rate of dissociation of the inclusion compound.
• Improve stability: Cyclodextrins can protect the drug from environmental factors such as light, heat, oxygen, and extend its validity.
• Convenient dosage form design: Cyclodextrin can improve the physical and chemical properties of drugs and facilitate the preparation of solid, liquid, gel and other dosage forms.

Service Details

With our strong expertise in cyclodextrin-based nanotechnology, Creative BioMart Nanocage continues contributing to the development of novel drug delivery systems.

We can provide these services in the preparation process:

• Custom cyclodextrin types. Depending on the nature and needs of the drug, choose the appropriate type of cyclodextrin, such as alpha, beta, or gamma-type cyclodextrin. β-cyclodextrin is often used as a drug carrier due to its suitable inclusion capacity, solubility and low irritability.
• Improve drug delivery rate. To further improve the efficiency of drug delivery, cyclodextrin inclusion compounds can be integrated into nanogels or microgels. These cross-linked polymer networks can be structurally engineered to accommodate the delivery of hydrophobic drugs and can effectively deliver hydrophilic drugs.
• Evaluation and optimization. During the preparation process, the physical and chemical properties of the drug carrier, drug release behavior, and biocompatibility need to be evaluated and optimized to ensure the safety and effectiveness of the final product.

Why choose us?

• Drug delivery solution experts. The expert team of Creative BioMart Nanocage has a multidisciplinary background.
• We can provide customized services. Not limited to the types of services mentioned above, products can be designed according to your specific needs.
• We have advanced equipment and production technology.
• Safe and reliable production process.

Creative BioMart Nanocage provides cyclodextrin-based delivery design services to meet the scientific research needs of customers. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

References

1. Liu, H.; et al. Pharmacokinetics and pharmacodynamics of cyclodextrin-based oral drug delivery formulations for disease therapy. Carbohydr Polym. 2024;329:121763.
2. Najm, A.; et al. Chitosan and Cyclodextrins-Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers. Pharmaceutics. 2023;16(1):43.