Liposome-based Drug Delivery Platform
Liposomes are phospholipid vesicles consisting of one or more concentric lipid bilayers enclosing discrete aqueous spaces. The hydrophilic part is mainly phosphoric acid bound to a water-soluble molecules, and the hydrophobic part contains two fatty acid chains with 10-24 carbon atoms. Liposomes can be classified into various classes based on the size and number of bilayers, their composition, and the way they are prepared. The remarkable ability of liposome systems to entrap both lipophilic and hydrophilic compounds allows them to encapsulate a wide variety of drugs.
Figure 1. Schematic representation of liposomes (Nsairat, H.; et al. 2022)
The drug delivery system is an essential part of the pharmaceutical industry, where the focus is to provide the drug to the target organ with maximum efficiency and minimum side effects. With the advancement of technology, various drug delivery systems have been developed to fulfill this requirement. One such innovative technology is the liposome-based drug delivery system, which has gained significant popularity in recent years.
Liposomes are the most common and best-studied nanocarriers for targeted drug delivery, which have had a major impact on the biomedical field. Liposome-based drug delivery systems are widely used because of their numerous considerable advantages, including biocompatibility, capacity for self-assembly, and ability to carry large drug payloads. Encapsulation of drugs within liposomes avoids their premature dilution, inactivation and degradation in the circulation. In addition, liposomes themselves have minimal toxicity and are considered pharmacologically inactive, and recent studies have shown that they are not as immunologically inert as once thought. So far, liposome delivery system has been successfully used for the encapsulation of various drug molecules such as paclitaxel, acyclovir, tropicamide, cyclosporine, and dithranol.
Figure 2. Schematic representation of the different types of liposomal drug delivery systems (Sercombe, L.; et al. 2015)
Liposome-based Drug Delivery Platform We Offer
At Creative BioMart Nanocage, we have assembled experts in the fields of nanotechnology, drug design, cytology, toxicology, and preclinical evaluation to form this powerful liposome-based drug delivery platform. On this platform, we provide strong support for the development of liposome-based drug delivery systems for drug candidates through a series of excellent services.
Our services include:
- Liposome formulation: We use state-of-the-art equipment and techniques to develop efficient and effective liposome formulations that can encapsulate a range of drugs.
- Liposome optimization: We optimize the liposome formulation to achieve maximum drug loading and efficiency, as well as to ensure stability during storage and transport. Including but not limited to strategies such as changing lipid composition, charged lipids, adding surface coatings and ligands, active targeting, and triggered release.
- Targeted drug delivery: We can functionalize the liposomes with specific ligands to achieve targeted drug delivery to the site of action.
- In vitro and in vivo evaluation: We perform in vitro and in vivo evaluation of the liposome-based drug delivery system to assess its efficacy and safety.
Provided by Clients
Please inform us of your specific liposome-based drug delivery service details, and we can provide customized solutions for different projects.
Confidentiality Statement
We attach great importance to confidentiality, sign a confidentiality agreement before communicating with you, and adopt multiple firewalls and safeguards to protect your privacy.
Why Choose Us?
Creative BioMart Nanocage provides corresponding liposome-based drug delivery service. We have many years of experience in liposome-based drug delivery, and our services have proven to be very useful for understanding the different stages of nanocage development (even in different fields such as materials science). The Creative BioMart Nanocage team has worked in this field for more than ten years and published his research results in top scientific journals. If you have any demand for gold nanocages modification service, please feel free to contact us.
Reference
- Nsairat, H.; et al. Liposomes: structure, composition, types, and clinical applications. Heliyon. 2022.
- Sercombe, L.; et al. Advances and Challenges of Liposome Assisted Drug Delivery. Frontiers in Pharmacology. 2015.
