Biomacromolecules Drug Carriers Design
Introduction to Biomacromolecules Drug Carriers
Natural biomacromolecules have attracted increased attention as carriers in biomedicine in recent years because of their inherent biochemical and biophysical properties including renewability, nontoxicity, biocompatibility, biodegradability, long blood circulation time and targeting ability.
Exploiting extracellular vesicles as carriers for biological therapeutics is a promising strategy to overcome these issues and to achieve efficient delivery to the cytosol of target cells. Exosomes are a well-studied class of extracellular vesicles known to carry proteins and nucleic acids, making them especially suitable for such strategies.
The ideal carriers should be safe, efficient and have optimal bioavailability. In addition, stability, nontoxicity and non-immunogenicity, and targeting ability to a specific site are very important. Biomacromolecule-based drug carriers are nontoxic, non-immunogenic and have high drug loading content, good biocompatibility and targeting ability. Meanwhile, they are also capable of controlled and sustained drug release.
Advantages of Biomacromolecules Drug Carriers
Biomacromolecules drug carriers may have advantages over synthetic material-based carriers in terms of stability, biocompatibility and targeting.
- Targeting: biomacromolecular drug carriers can be designed to have specific targeting properties in order to deliver drugs to specific cells or tissues. This can improve the effectiveness of the drug and reduce side effects.
- Biocompatibility: biological macromolecule drug carriers usually have good biocompatibility and can interact with various substances in the biological body without causing adverse reactions.
- Stability: Biological macromolecule drug carriers usually have high stability and can remain active in the body for a long time. This helps the drug to be consistently released in the body, which improves efficacy.
- Controlled release: Biological macromolecule drug carriers can achieve controlled release of drugs by adjusting their structure or properties. This helps maintain the effective concentration of the drug in the body, reducing the dose and frequency.
Biomacromolecules Drug Carriers Design Services We Offer
Creative BioMart Nanocage can provide you with a series of biomacromolecules drug carriers design services, from production, isolation to characterization, you only need to briefly describe your experimental needs for us, and we will provide you with professional services to meet your scientific research needs. Our service include but not limited to:
Exosomes
- Exosomes are extracellular vesicles (EVs) that can arise in normal or abnormal cells and mediate intercellular communication by translocating biologically active cargo such as nucleic acids, proteins, lipids, and metabolites to target cells, thereby regulating target cell and tissue functions. Besides engineering exosomes vesicles through genetic or nongenetic methods to enhance their efficacy and targeting ability, Creative BioMart Nanocage also provides therapeutic proteins that used in the treatment of various diseases.
Virus-like Nanoparticles (VLPs)
- Nanoparticles (NPs) based drug delivery agents, including liposomes, polymer NPs, metal NPs and protein-based NPs have the potential to provide a safe targeted delivery by encapsulating therapeutic cargo inside the particle. We provide various types of engineered VLPs, including animal virus-based, bacteriophage-based and plant virus based, etc.
Bacterial Outer Membrane Vesicles
- Analyses of OMVs showed that OMVs contain multiple bacteria-derived components, including enzymes, virulence factors, bacteria-specific antigens and various pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS), lipoprotein, DNA, RNA, peptidoglycan, and others. Our expert team has extensive experience in OMV research and production, and provides customers with a series of OMV-related services, including production, purification, and functionalization.
Fig1. Exosome structure, composition, and cargo. (Shaheera Fatima, 2024)
Why Choose Us?
- Sufficent drug delivery solution experts
- Strong scientific background
- Customized service
- Development-focused portfolio of services for manufacturers
- Safe and reliable production processes
Creative BioMart Nanocage provides professional biomacromolecules drug carriers design services to meet the scientific research needs of customers. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.
References
- Pan, C., et al. Delivery Strategies, Structural Modification, and Pharmacological Mechanisms of Honokiol: A Comprehensive Review. Chem Biodivers. Published online February 2, 2024.
- Han, M., et al. Regulated cell death in glioma: promising targets for natural small-molecule compounds. Front Oncol. 2024;14:1273841.
- Fatima, S., et al. Navigating the brain: the role of exosomal shuttles in precision therapeutics. Front Neurol. 2024;14:1324216.
