Ferritin PEGlyation Service
PEG is often used for protein modification, and the connection between protein and PEG (ie, PEG of protein) has important application value in the fields of pharmacy and biotechnology. PEG can effectively solve the problems in the application of protein drugs, including: rapid in vivo clearance, immunogenicity, physical and chemical instability (such as aggregation, adsorption, deamination, tailoring, oxidation, etc.), and enzyme degradation. Therefore, PEG is considered to be the most promising way to improve the efficacy of protein therapy in clinical trials. Creative BioMart Nanocage has well-trained technicians and the most advanced ferritin PEGlyation service equipment. We will provide you with high-quality protein nanocage modification services. Creative BioMart Nanocage focuses on comprehensive services for ferritin PEGlyation service.
Figure 1. Ferritin is modified by PEG (PEG-maleimide) and fluorescently modified (rhodamine-NHS) for imaging and diagnostic reagents. (Vannucci L, Falvo E, Fornara M, et al.2012)
Ferritin PEGlyation service We Offer
- Creative BioMart Nanocage provides high-quality ferritin PEGlyation services. Our PEG-modified ferritin has excellent biocompatibility and biomolecule re-modification ability.
- Creative BioMart Nanocage nanocage experts will professionally consider the length and conformational conditions of the PEG chain, PEG end and characterization methods according to your scientific needs.
- Creative BioMart Nanocage activates the selection of PEG modifiers, targeted modification of proteins, PEG modification methods, such as liquid phase modification or solid phase media-assisted modification, and PEG modification reaction conditions such as pH, protein to PEG molar ratio, reaction time, reaction temperature, etc. The control can realize the modification of specific sites.
- Creative BioMart Nanocage will further purify the ferritin after PEG modification.
Our Advantages
- Creative BioMart Nanocage’ PEG modified ferritin can hinder the recognition of foreign proteins by antibodies in the body, thereby reducing the immunogenicity and immunoreactivity of the protein, and reducing the degradation of the protein by proteolytic enzymes.
- Creative BioMart Nanocage can efficiently produce highly functionalized ferritin, and can easily load targeting moieties, therapeutic agents and/or imaging agents.
- Creative BioMart Nanocage will complete your project on time and efficiently. We have professional after-sales service: to provide customers with efficient, fast and practical solutions.
- We have established a professional after-sales service team to provide customers with efficient, fast and practical solutions.
Service Procedure
Please inform us of your ferritin PEGlyation service project details through online consultation. We will reply to you in time and provide you with a comprehensive evaluation report on your project, including the feasibility of the project and the detailed experimental plan designed by our professionals.
Why choose us?
Creative BioMart Nanocage provides professional ferritin PEGlyation service to meet the scientific research needs of customers. Creative BioMart Nanocage relies on world-class technical expertise, we provide customers with the best quality one-stop ferritin PEGlyation service, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.
Reference
- Vannucci L, Falvo E, Fornara M, et al. Selective targeting of melanoma by PEG-masked protein-based multifunctional nanoparticles. Int J Nanomedicine. 2012; 7: 1489–1509.
