Bacterial Outer Membrane Vesicles
Introduction to Bacterial Outer Membrane Vesicles
Outer membrane vesicles (OMVs) are spherical vesicles in the size range 20-300 nm formed by lipid bilayer membranes which derived from the outer membrane of bacteria. Analyses of OMVs showed that OMVs contain multiple bacteria-derived components, including enzymes, virulence factors, bacteria-specific antigens and various pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS), lipoprotein, DNA, RNA, peptidoglycan, and others. OMVs have developed a number of biomedical-relevant applications based on their intrinsic properties associated with bacteria and vesicles. The vesicular structure of OMVs has been developed as drug delivery vehicle to achieve cell-specific targeting and greatly increase drug accumulation at the targeted site. Cargo can be encapsulated in the lumen of the OMVs or attached to the surface of the OMVs.
Advantages of Bacterial Outer Membrane Vesicles
- OMVs are biocompatible. Thus, they can be easily functionalized with a variety of drugs, proteins, and other therapeutics. This makes them ideal candidates for targeted drug delivery, as they can be engineered to deliver payloads directly to sites of infection or disease.
- OMVs have diversity. OMVs produced by different bacteria have different properties and functions, which provides a wide range of options for selecting the OMVs that are best suited for a particular application.
- OMVs have a certain degree of security. As a naturally occurring substance, OMVs may be more acceptable among consumers, especially among people who have reservations about synthetic materials.
Fig1. The applications of bacterial outer membrane vesicles. (Min Li, 2020)
Service Details
Creative BioMart Nanocage's expert team has extensive experience in OMV research and production, and provides customers with a series of OMV-related services, including production, isolation, purification, and functionalization. We will gain an in-depth understanding of our customers' specific needs and develop custom solutions that meet their requirements. We believe OMVs have the potential to revolutionize the fields of drug delivery and vaccine development, and are excited to be at the forefront of this new technology with you.
- Isolation. We commonly separated OMVs from bacterial culture supernatants based on their physical or biochemical properties. Methods used to isolate OMVs include ultracentrifugation, ultrafiltration, protein precipitation and so on.
- OMV characterization. OMVs have multiple properties, such as size, potential, morphology and composition. We provide different characterization methods including size-based characterization, morphology-based characterization and omposition analysis.
- Modulation of the OMV properties. The properties of OMVs could be finely controlled by bioengineering according to your requirements.
Why choose us?
- Professional research team
- Safe and reliable production process
- Widely used in the field of product production technology
- Customized service
Creative BioMart Nanocage keeps pace with The Times and continues to innovate. We continue to carry out technological innovation and research and development, improve the performance and application range of OMVs, and maintain the leading position in the industry. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.
References
- Li, M.; et al. Bacterial outer membrane vesicles as a platform for biomedical applications: An update. J Control Release. 2020;323:253-268.
- Collins, S.M, Brown, A.C. Bacterial Outer Membrane Vesicles as Antibiotic Delivery Vehicles. Front Immunol. 2021;12:733064.
