Polymeric Nanocarrier
Introduction to Polymeric Nanocarrier
Nowadays, therapies using nanoparticles have widely been achieved for the treatments of cancer, diabetes, allergy, infection, and inflammation. The reasons that nanoparticles have been used in the therapeutic application are the fact that nanoparticles exist in the same size domain as proteins. Their large surface areas can also allow for displaying a large number of surface functional groups such as ligands. Furthermore, they have a rapid absorption and release behavior provided by the high abilities of their diffusion and volume change. And the particle sizes and surface characteristics of nanoparticles can be tailored or controlled.
Polymeric micelles are nanoscopic spherical structures formed by amphiphilic block copolymers. Both the inherent core and shell of polymeric micelles could be modified to make them particularly well suited for drug delivery purposes, and in the meantime achieve abilities to reduce toxicities, enhance target delivery and improve the therapeutic efficacy.
Hydrophobic or hydrophilic drugs can be incorporated into polymer nanocarriers either by nanoencapsulation or surface conjugation, which protect drugs from degradation, facility cell entry, increase solubility and bioactivity. Polyester-based nanoparticles, formed by emulsion or nanoprecipitation techniques can be designed to have a range of degradation times. The particle degradation and drug release kinetics are controlled by the physiochemical properties of the polymer (e.g., molecular weight, hydrophobicity, and polydispersity).
Fig1. Major classes of nanoparticles that are in clinical trials and some of their properties. (Mark E Davis, 2008)
How Can We Help?
At Creative BioMart Nanocage, we provide various types of off-the-shelf polymers synthesis, such as poly(N-isopropylacrylamide-b-butylmethacrylate) (PNIPAM), polypyrrole (PPy), poly(lactide) (PLA), poly(glycolide) (PGA), and the copolymer of lactide and glycolide referred to as poly(lactide-co-glycolide) (PLGA).
Customized polymerization services can provide customers with polymers for specific needs, such as specific molecular weights, functionalization, or specific nanocarrier designs. Here are several types of polymers for specific needs that a custom polymerization service may offer:
- Polymer with specific molecular weight: Molecular weight is a key factor in determining the physical properties of the polymer, such as melting point, glass transition temperature, mechanical strength, etc. Custom polymerization services can provide polymers with precise control of molecular weight to meet specific application needs.
- Functional polymers: By introducing specific functional groups in the polymer chain, additional chemical, biological, or physical properties can be conferred on the polymer. For example, polymers that introduce fluorescent labels can be used for imaging and detection, while polymers that introduce bioactive groups can be used for drug delivery and tissue engineering.
- Polymers with special structures and topologies: In addition to linear polymers, polymers with special structures such as stars, combs, and crosslinks can also be customized, which have a significant impact on the solution behavior and mechanical properties of the polymer.
- Copolymers and block polymers: Copolymers and block polymers with a variety of properties can be prepared by combining different monomers. These polymers are widely used in thermoplastic elastomers, surfactants, compatibilizers and so on.
Why choose us?
- Technology development and innovation capabilities
- Quality and thorough knowledge of regulations
- Responsiveness and flexibility in creating and developing products
- Superb industry knowledge and expertise
- We will complete your project on time according to your scientific research needs.
Creative BioMart Nanocage provides polymeric nanocarrier design services to meet the scientific research needs of customers. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.
Reference
- Davis, ME.; et al. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. 2008;7(9):771-782.
