DNA Nanocage Folic Acid Modification
Nanotechnology applied to drug delivery systems can improve the solubility of drugs, change their biodistribution and in vivo kinetic properties, and can also control drug release, avoiding the lack of tissue specificity and potential toxicity. DNA nanocages modified with small molecule ligands can achieve specific targeting functions. Now, Creative BioMart Nanocage offer you with professional DNA nanocage folic acid modification service according to your scientific needs.
Research progress in DNA nanocage folic acid modification
Lee et al. [1] used folate-modified DNA tetrahedrons to deliver siRNA, and the results showed that the gene silencing effect of the folate-modified group was significantly higher than that of the non-modified group. Therefore, the modification of folic acid can greatly improve the targeting of DNA nanocages.
Figure 1. DNA nanocage folic acid modification. (Lee et al.2012)DNA Nanocage Folic Acid Modification We Offer
Since folic acid can specifically bind to the folate receptor overexpressed on the surface of tumor cells, the use of folic acid to modify drugs or drug carriers can achieve specific tumor targeting. We offer you with the following professional DNA nanocage folic acid modification service:
- Creative BioMart Nanocage provides professional DNA nanocage folate modification services. The modified DNA nanocage can specifically target folate receptors on the surface of tumor cells.
- In addition, we modify the DNA nanocage with folic acid, which can not only improve the surface properties of the DNA nanocage, but also enhance the targeting properties and significantly improve the anti-tumor effect.
Our Advantages
- Creative BioMart Nanocage provides you with a variety of DNA nanocage folic acid modification service for your choice, our DNA nanocage folic acid modification service service can easily loaded with targeting moieties, therapeutics, and imaging agents.
- Creative BioMart Nanocage will complete your project on time and efficiently. We have professional after-sales service: which has been established to provide customers with efficient, fast, practical and feasible solutions.
- We have established a professional after-sales service team to provide customers with efficient, fast and practical solutions.
Service Procedure
Please inform us of your DNA nanocage folic acid modification service details through online consultation. We will reply to you in time and provide you with a comprehensive evaluation report on your project, including the feasibility of the project and the detailed experimental plan designed by our professionals. As our condition optimization is completed, the result report and final product will be delivered to you immediately.
Why choose us?
Creative BioMart Nanocage provides professional DNA nanocage folic acid modification service to meet the scientific research needs of customers. Creative BioMart Nanocage relies on world-class technical expertise, we provide customers with the best quality one-stop DNA nanocage folic acid modification service, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.
Reference
- Lee H, Lytton-Jean AK, Chen Y, et al. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat Nanotechnol. 2012, 7( 6) : 389 -393.
