Inorganic Nanoparticles
Introduction to Inorganic Nanoparticles
In biomedicine, nanoparticles (NPs) are attractive support because the tunable size is compatible with cells (10–100 μm), viruses (20–450 nm), proteins (5–50 nm) and nucleic acids (2 nm wide by 10–100 nm long). This is of special importance to drug delivery applications because NPs are small enough to move inside the body without disruptingnormal functions and can distribute to places that are inaccessible to other materials. Other important and unique advantages of NPs include high surface to mass ratios, characteristic quantum properties and their ability to adsorband carry other molecules. In a drug/carrier complex system, drugs can be bound to NPs through a solid solution ordispersion; adsorption to the surface; or chemical linkage.
Fig1. A visual representation of a PLGA-loaded NP crossing mucosal barrier in the lungs. (Victoria Jessamine, 2024)
Inorganic Nanoparticles Services We Offer
Creative BioMart Nanocage achieves precise design through engineering strategies that utilizethe abundant chemically-active sites on MNPs surface for biomolecule conjugation. This enables many intendedfunctions such as prevention of aggregation, long-lasting circulation in the blood stream, target specificity tolesion tissue, optical detectability and therapeutic delivery. In the process we can provide the following services:
- Needs analysis: Understanding treatment needs, drug properties, and expected targets.
- Material selection: According to the demand analysis results, select the appropriate inorganic nanomaterials, such as metal nanoparticles, silicon-based nanomaterials, etc.
- Surface modification: Surface modification of inorganic nanomaterials to improve their biocompatibility, stability and drug loading capacity.
- Drug loading: Loading drug molecules onto inorganic nanomaterials through physical adsorption, chemical bonding or encapsulation.
- Functional design: According to the needs, the functional design of inorganic nanoparticles, such as the introduction of targeting ligands, fluorescent labeling, etc.
- Performance evaluation: Evaluation of the performance of the inorganic nanion drug delivery system, such as drug release behavior, cell uptake efficiency, biological distribution, etc.
Several surface coating materials have been appliedto MNPs including polymer, organic surfactant, metals and bioactive molecules. Below are other NPs that have been carried out in different studies:
- Metallic NPs Examples: Iron oxide NPs, Gold NPs, Silver NPs.
- Non-metallic NPs Examples: Silica NPs.
- Polymer/small ligand functionalized NPs.
- Nanoshperes, nanorods, nanotubes Example: Carbon nanotubes (CNTs).
Why choose us?
- The expert team of Creative BioMart Nanocage has a multidisciplinary background, including medicine, pharmacy, molecular biology, bioinformatics, etc. We attach great importance to innovation and practice.
- We work with scientists from many pharmaceutical and biotech companies. We pay special attention to nanoparticles drug carriers related services and are committed to contributing to more customers.
- We will complete your project on time according to your scientific research needs. We have a strict quality management system to provide customers with efficient, fast and reliable solutions.
- Our experts could design suitable drug delivery carriers according to your requirements.
Creative BioMart Nanocage is your reliable partner in studying of novel drug delivery systems. We will support you with superb expertise, advanced equipment, and satisfactory customer service. If you are interested in our services, please feel free to contact us.
References
- Jessamine, V.; et al. The application of nanoparticles as advanced drug delivery systems in Attenuating COPD. Heliyon. 2024;10(3):e25393.
- Wang, Y.; et al. Polymeric nanoparticles (PNPs) for oral delivery of insulin. J Nanobiotechnology. 2024;22(1):1.
