Protein Nanocage Amphiphilic Modification

Intelligent nanomaterials with high stability, suitable pharmacokinetics and effective cell permeability to deliver cargo molecules to target cells have always been the requirements of an ideal drug delivery system. Examples of naturally-derived nanocarriers include protein nanocages, such as viruses, ferritin, and many other cage-like structures formed by the self-assembly of protein subunits. Modifications can be made through chemical and genetic methods to improve drug delivery. A biocompatible and modifiable protein nanocarrier is a promising candidate for tumor targeted drug delivery. However, it is challenging to effectively load hydrophobic drugs, not to mention to upload both hydrophilic and hydrophobic drugs on one protein nanocarrier. Now, Creative BioMart Nanocage provides professional protein nanocage amphiphilic modification services according to your scientific needs.

Protein Nanocage Amphiphilic Modification We Offer

•  Creative BioMart Nanocage provides amphiphilic multi-drug protein nanocages with dual targeting properties. We replaced the fifth helix of the human H-ferritin (HFn) subunit with a functional motif composed of hydrophobic-hydrophilic-RGD peptides. The side effects of the amphipathic nanocage will be significantly reduced, and it has a synergistic effect on the drug resistance of some tumors. Therefore, the amphipathic nanocage modification represents a new type of protein nanocarrier for targeted combination chemotherapy.
• Our researchers usually require a full understanding of nanocage modification details. They can quickly understand the project situation through a simple description, and quickly establish a feasible research plan according to the client's needs, saving a lot of time for literature research.

Our Advantages

• Creative BioMart Nanocage cooperates with scientists from many pharmaceutical and biotechnology companies. We have a wealth of knowledge and experience to provide quality assurance services.
• Creative BioMart Nanocage will complete your project on time and efficiently. We have professional after-sales service: which has been established to provide customers with efficient, fast, practical and feasible solutions.
• We have established a professional after-sales service team to provide customers with efficient, fast and practical solutions.

Service Procedure

Please inform us of your protein nanocage amphiphilic modification project details through online consultation. We will reply to you in time and provide you with a comprehensive evaluation report on your project.

Why choose us?

Creative BioMart Nanocage provides professional protein nanocage amphiphilic modification service to meet the scientific research needs of customers. Creative BioMart Nanocage relies on world-class technical expertise, we provide customers with the best quality one-stop protein nanocage amphiphilic modification, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

Reference

• Wang Z, Zhang S, Zhang R, et al. Bioengineered Dual-Targeting Protein Nanocage for Stereoscopical Loading of Synergistic Hydrophilic/Hydrophobic Drugs to Enhance Anticancer Efficacy. Advanced Functional Materials, 2021, 31.