DNA Nanocage Nucleic Acid Modification
With the emergence of more programmable nucleic acid sequences and the improvement of DNA modification methods, self-assembled DNA nanocages have great application prospects in the fields of drug carriers, in vitro diagnostics, biological testing, biomedicine, and materials science. The DNA nanocage has been modified to avoid rapid clearance of drugs during the systemic circulation, reduce the amount of drugs used, and at the same time enhance the uptake effect of cells, thereby improving drug targeting.
Research Progress in Nucleic Acid Modification of DNA Nanocage
Liu et al. introduced ATP aptamers into the DNA nanocage structure, and prepared multilayer DNA nanocages that can respond to ATP through layer-by-layer assembly. After the cage is activated by ATP, the layers can be separated to release the contained drugs. Li et al. used functionalized multivalent DNA tetrahedrons modified with unmethylated CpG structure to activate macrophages. Therefore, CpG-modified DNA nanocages can be used in immunotherapy for infectious diseases, allergic diseases, and tumors.
Figure 1. ATP-activated layer separation. The assembly of multilayered DNA nanocages. The layers can be separated in response to a chemical cue, ATP. (Liu et al. 2015)DNA Nanocage Nucleic Acid Conjugate We Offer
Functional modification can improve the defects of the DNA nanocage structure, improve the targeting of the DNA nanocage, and expand the application range of the DNA nanocage. Now, Creative BioMart Nanocage provide you with the following nucleic acid sequences modifications service but not limited to:
- Nucleic acid sequence mTOR-siRNA
- Bcl-2 /Bcl-XL mRNA-siRNA
- GFP-siRNA
- CpG sequence
Our Advantages
- Creative BioMart Nanocage has experts in DNA nanocage nucleic acid modification. You only need to briefly describe your service requirements. Our experts will provide you with customized Creative BioMart Nanocage and have successfully supported multiple DNA nanocage nucleic acid modification services.
- Our team has deep scientific literacy and years of experience in the industry, and can bring more profound and in-depth professional knowledge and rich experience to customers.
- With the help of advanced nano cage platform, our team is committed to providing customers with a full range of nano cage modification services.
Figure 2. Schematic showing of the assembly of CpGbearing DNA tetrahedron and its immunostimulatory effect.( Li J, et al.2011) Why Choose Us?
As one of the world's leading companies in the nanocage industry! Creative BioMart Nanocage provide DNA nanocage nucleic acid modification service for our customers. With more than 8 years of experience in the field of bioinformatics, we are willing to provide our customers with the best quality service! Contact us for all details! Our services can be contracted according to confidentiality clauses and other specific conditions negotiated with customers. Please contact us for more details.
References
- Arun Richard Chandrasekaran, Oksana Levchenko. Chem. Mater.2016, 28, 16, 5569-5581.
- Liu Z, Tian C, Yu J, et al. Self-assembly of responsive multilayered DNA nanocages. J Am Chem Soc, 2015, 137(5):1730-1733.
- Li J, Pei H, Zhu B, et al． Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides．ACS Nano, 2011, 5 (11) : 8783-8789.
